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1

Posaconazole (Noxafil, SCH 56592), a new azole antifungal drug, was a discovery based on the isolation and mass spectral characterization of a circulating metabolite of an earlier lead (SCH 51048)

Amin A. Nomeir, Birendra N. Pramanik, Larry Heimark, Frank Bennett, John Veals, Peter Bartner, Maryjane Hilbert, Anil Saksena, Paul McNamara, Viyyoor Girijavallabhan, Ashit K. Ganguly, Raymond Lovey,

Journal:

Journal of Mass Spectrometry

Year:

2008

Language:

english

File:

PDF, 722 KB

english, 2008

2

Chiral high-performance liquid chromatographic analysis of antifungal SCH 56592 and evaluation of its chiral inversion in animals and humans

Hong Kim, Chin-Chung Lin, Mark Laughlin, Raymond Lovey, Anil Saksena, Larry Heimark, Amin A. Nomeir

Journal:

Year:

2000

Language:

english

File:

PDF, 217 KB

english, 2000

3

ChemInform Abstract: Chemical Modifications and Structure—Activity Studies of Ziracin and Related Everninomicin Antibiotics.

Ashit K. Ganguly, Jinping L. McCormick, Anil K. Saksena, Pradip R. Das, Tze-Ming Chan

Journal:

Year:

1999

File:

PDF, 24 KB

1999

4

ChemInform Abstract: Structural Characterization of the Oligosaccharide Antibiotics Everninomicins by Negative Ion FAB and ESI/MS.

Birendra N. Pramanik, Petia A. Shipkova, Peter L. Bartner, Larry Heimark, Yan-Hui Liu, Pradip R. Das, Anil K. Saksena, Olga Z. Sarre, Viyyor M. Girijavallabhan, Ashit K. Ganguly

Journal:

Year:

2001

File:

PDF, 24 KB

2001

5

Synthesis and Antifungal Activity of the 2,2,5-Tetrahydrofuran Regioisomers of SCH 51048.

Raymond G. Lovey, Anil K. Saksena, Viyyoor M. Girijavallabhan, Paul Blundell, Henry Guzik, David Loebenberg, Raulo M. Parmegiani, Anthony Cacciapuoti

Journal:

Year:

2002

Language:

english

File:

PDF, 36 KB

english, 2002

6

[3 + 2] Cycloaddition of Trimethylenemethane (TMM) to α,β-Unsaturated γ-Lactam. Preparation of 5,5-Fused Proline Surrogates.

Edwin Jao, Stephane Bogen, Anil K. Saksena, Viyyoor Girijavallabhan

Journal:

Year:

2003

File:

PDF, 81 KB

2003

7

An Unusual Acetonide Group Migration.

Anil K. Saksena, Viyyoor M. Girijavallabhan, Mohindar S. Puar, Birendra N. Pramanik, Pradip R. Das, Andrew T. McPhail

Journal:

Year:

2003

File:

PDF, 117 KB

2003

8

Preparation of (2,2-Dimethylhexahydrofuro[2,3-c]pyrrol-6-yl)methanol (I): A Conformationally Restricted Congener of Nonproteinogenic 3-Hydroxy-4-methylproline.

Edwin Jao, Stephane Bogen, Anil K. Saksena, Viyyoor Girijavallabhan

Journal:

Year:

2004

File:

PDF, 56 KB

2004

9

Carboxy-Mediated Stereoselective Reduction of Ketones with Sodium Triacetoxyborohydride: Synthesis of Novel 3,4-Fused Tetrahydropyran and Tetrahydrofuran Prolines.

Yi-Tsung Liu, Jesse K. Wong, Meng Tao, Rebecca Osterman, Mousumi Sannigrahi, Viyyoor M. Girijavallabhan, Anil Saksena

Journal:

Year:

2004

File:

PDF, 23 KB

2004

10

Retrograde Wallerian degeneration of cranial corticospinal tracts in cervical spinal cord injury patients using diffusion tensor imaging

Saurabh Guleria, Rakesh K. Gupta, Sona Saksena, Anil Chandra, R.N. Srivastava, Mazhar Husain, Ramkishore Rathore, Ponnada A. Narayana

Journal:

Journal of Neuroscience Research

Year:

2008

Language:

english

File:

PDF, 429 KB

english, 2008

11

Ring contraction reactions of 2-O-methanesulfonates of α-hydroxy-γ-lactones in aqueous medium to oxetane-2-carboxylic acids: A convenient synthesis of 3′-O-methyloxetanocin and a formal synthesis of oxetanocin

Anil K. Saksena, Ashit K. Ganguly, Viyyoor M. Girijavallabhan, Russell E. Pike, Yao-Tsung Chen, Mohindar S. Puar

Journal:

Tetrahedron Letters

Year:

1992

Language:

english

File:

PDF, 208 KB

english, 1992

12

PPL-catalyzed enzymatic asymmetrization of a 2-substituted prochiral 1,3-diol with remote chiral functionality: Improvements toward synthesis of the eutomers of SCH 45012

Raymond G. Lovey, Anil K. Saksena, Viyyoor M. Girijavallabhan

Journal:

Tetrahedron Letters

Year:

1994

Language:

english

File:

PDF, 308 KB

english, 1994

13

Highly stereoselective access to novel 2,2,4-trisubstituted tetrahydrofurans by halocyclization: Practical chemoenzymatic synthesis of Sch 51048, a broad-spectrum orally active antifungal agent

Anil K Saksena, Viyyoor M Girijavallabhan, Raymond G Lovey, Russell E Pike, Haiyan Wang, Ashit K Ganguly, Brian Morgan, Alexsey Zaks, Mohinder S Puar

Journal:

Tetrahedron Letters

Year:

1995

Language:

english

File:

PDF, 284 KB

english, 1995

14

Concise asymmetric routes to 2,2,4-trisubstituted tetrahydrofurans via chiral titanium imide enolates: Key intermediates towards synthesis of highly active azole antifungals SCH 51048 and SCH 56592

Anil K Saksena, Viyyoor M Girijavallabhan, Haiyan Wang, Yi-Tsung Liu, Russel E Pike, Ashit K Ganguly

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 287 KB

english, 1996

15

Total synthesis of the antifungal cyclic depsipeptides Sch 57697 and aureobasidin A

Edwin Jao, Alan B Cooper, Dinanath F Rane, Anil K Saksena, Jagdish Desai, James Wang, Viyyoor M Girijavallabhan, Ashit K Ganguly

Journal:

Tetrahedron Letters

Year:

1996

Language:

english

File:

PDF, 264 KB

english, 1996

16

Sch 51048, a novel broad-spectrum orally active antifungal agent: Synthesis and preliminary structure-activity profile

Anil K Saksena, Viyyoor M Girijavallabhan, Raymond G Lovey, Jagdish A Desai, Russell E Pike, Edwin Jao, Haiyan Wang, Ashit K Ganguly, David Loebenberg, Roberta S Hare, Anthony Cacciapuoti, Raulo M Par

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1995

Language:

english

File:

PDF, 314 KB

english, 1995

17

Novel inhibitors of the hepatitis C virus NS3 proteinase

Frank Bennett, Yi-Tsung Liu, Anil K. Saksena, Ashok Arasappan, Nancy Butkiewicz, Bimalendu Dasmahapatra, John S. Pichardo, F. George Njoroge, Naginbhai M. Patel, Yuhua Huang, Xiaozheng Yang

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2005

Language:

english

File:

PDF, 108 KB

english, 2005

18

Hydroxylated analogues of the orally active broad spectrum antifungal, Sch 51048 (1), and the discovery of posaconazole [Sch 56592; 2 or (S,S)-5]

Frank Bennett, Anil K. Saksena, Raymond G. Lovey, Yi-Tsung Liu, Naginbhai M. Patel, Patrick Pinto, Russel Pike, Edwin Jao, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, David Loebenberg, Haiyan Wang,

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 136 KB

english, 2006

19

Carboxy mediated stereoselective reduction of ketones with sodium triacetoxyborohydride: synthesis of novel 3,4-fused tetrahydropyran and tetrahydrofuran prolines

Yi-Tsung Liu, Jesse K. Wong, Meng Tao, Rebecca Osterman, Mousumi Sannigrahi, Viyyoor M. Girijavallabhan, Anil Saksena

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 267 KB

english, 2004

20

Stereoselective Grignard additions to N-formyl hydrazone: a concise synthesis of NoxafilR side chain and a synthesis of NoxafilR

Anil K. Saksena, Viyyoor M. Girijavallabhan, Haiyan Wang, Raymond G. Lovey, Frank Guenter, Ingrid Mergelsberg, Mohinder S. Puar

Journal:

Tetrahedron Letters

Year:

2004

Language:

english

File:

PDF, 255 KB

english, 2004

21

Synthesis of (+)-8-methyl cercosporamide: Stereochemical correlation of natural (−)-cercosporamide with (+)-usnic acid

Alan B. Cooper, James Wang, Anil K. Saksena, Viyyoor Girijavallabhan, K.Ganguly Ashit, Chan Tze-Ming, Andrew T. McPhail

Journal:

Year:

1992

Language:

english

File:

PDF, 754 KB

english, 1992

22

Neogermine 7,9,14-orthoesters: synthesis and use in the preparation of hypotensive germine 3,7,15-triesters

Michael J. Green, Robert P. Hatch, Anil K. Saksena

Journal:

Year:

1985

Language:

english

File:

PDF, 677 KB

english, 1985

23

A convenient route to carbocyclic analogs of nucleosides: (±) aristeromycin

Anil K. Saksena

Journal:

Tetrahedron Letters

Year:

1980

Language:

english

File:

PDF, 261 KB

english, 1980

24

Total synthesis and absolute stereochemistry of the antifungal dipeptide Sch 37137 and its 2S,3S - isomer

Dinanath F. Rane, Viyyoor M. Girijavallabhan, Ashit K. Ganguly, Russell E. Pike, Anil K. Saksena, Andrew T. McPhail

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 257 KB

english, 1993

25

A synthesis of nikkomycin Z: Improved synthesis and protection of the pyridyl γ-hydroxy-α-aminobutanoic acid component

Anil K. Saksena, Raymond G. Lovey, Viyyoor M. Girijavallabhan, Henry Guzik, Ashit K. Ganguly

Journal:

Tetrahedron Letters

Year:

1993

Language:

english

File:

PDF, 333 KB

english, 1993

26

Structure of protoveratrine C, a new alkaloid from provoveratrine

Anil K. Saksena, Andrew T. McPhail

Journal:

Tetrahedron Letters

Year:

1982

Language:

english

File:

PDF, 233 KB

english, 1982

27

Identity of coleonol with forskolin: structure revision of a base-catalysed rearrangement product

Anil K. Saksena, Michael J. Green, Ho-Jane Shue, Jesse K. Wong, Andrew T. McPhail, Paul M. Gross

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 258 KB

english, 1985

28

Synthesis of 7,8-acetylenic analogs of hexahydro leukotriene-E4 with agonist and antagonist activities: convenient stereoselective routes to E- and Z-enynes

Anil K. Saksena, Michael J. Green, Pietro Mangiaracina, Jesse K. Wong, William Kreutner, Arax R. Gulbenkian

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 284 KB

english, 1985

29

Synthesis of butanoic acid 4,4′-[(4E, 6Z, 9Z-pentadecatrien-2-ynylidene)-bis with leukotriene- like activity: Novel acetylenic acetals and dithioacetals as antagonists of leukotriene-C4

Anil K. Saksena, Michael J. Green, Pietro Mangiaracina, Jesse K. Wong, William Kreutner, Arax R. Gulbenkian

Journal:

Tetrahedron Letters

Year:

1985

Language:

english

File:

PDF, 247 KB

english, 1985

30

A general stereocontrolled route to carbocyclic C-nucleosides: (±) carba-showdowmycin

Anil K. Saksena, Ashit K. Ganguly

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 229 KB

english, 1981

31

Carbocyclic analogs of C-nucleosides: a key intermediate via a novel and efficient CC ring scission

Anil K Saksena, Andrew T McPhail, Kay D Onan

Journal:

Tetrahedron Letters

Year:

1981

Language:

english

File:

PDF, 220 KB

english, 1981

32

[3+2] Cycloaddition of trimethylenemethane (TMM) to α,β-unsaturated γ-lactam. Preparation of 5,5-fused proline surrogates

Edwin Jao, Stephane Bogen, Anil K Saksena, Viyyoor Girijavallabhan

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 111 KB

english, 2003

33

An unusual acetonide group migration

Anil K. Saksena, Viyyoor M. Girijavallabhan, Mohindar S. Puar, Birendra N. Pramanik, Pradip R. Das, Andrew T. McPhail

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 151 KB

english, 2003

34

DETERMINATION OF THE ABSOLUTE STEREOCHEMISTRY AT THE C16 ORTHOESTER OF EVERNINOMICIN ANTIBIOTICS; A NOVEL ACID-CATALYZED ISOMERIZATION OF ORTHOESTERS

Ashit K Ganguly, Jinping L McCormick, Tze-Ming Chan, Anil K Saksena, Pradip R Das

Journal:

Tetrahedron Letters

Year:

1997

Language:

english

File:

PDF, 506 KB

english, 1997

35

A convenient degradation of polyoxin D to uracil polyoxin C: access to key intermediates and synthesis of antifungal α-aminoacyl derivatives of UPOC

Alan B. Cooper, Jagdish Desai, Raymond G. Lovey, Anil K. Saksena, V.M. Girijavallabhan, Ashit K. Ganguly, David Loebenberg, Raulo Parmegiani, Anthony Cacciapuoti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1993

Language:

english

File:

PDF, 502 KB

english, 1993

36

Synthesis and antifungal activity of the 2,2,5-tetrahydrofuran regioisomers of SCH 51048

Raymond G Lovey, Anil K Saksena, Viyyoor M Girijavallabhan, Paul Blundell, Henry Guzik, David Loebenberg, Raulo M Parmegiani, Anthony Cacciapuoti

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2002

Language:

english

File:

PDF, 151 KB

english, 2002

37

Chemical modifications and structure activity studies of ziracin and related everninomicin antibiotics

Ashit K Ganguly, Jinping L McCormick, Anil K Saksena, Pradip R Das, Tze-Ming Chan

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1999

Language:

english

File:

PDF, 332 KB

english, 1999

38

Multiple-stage mass spectrometric analysis of complex oligosaccharide antibiotics (everninomicins) in a quadrupole ion trap

Guodong Chen, Birendra N Pramanik, Peter L Bartner, Anil K Saksena, Michael L Gross

Journal:

Journal of the American Society for Mass Spectrometry

Year:

2002

Language:

english

File:

PDF, 326 KB

english, 2002

39

Structure elucidation of everninomicin-6, a new oligosaccharide antibiotic, by chemical degradation and FAB-MS methods

Peter Bartner, Birendra N. Pramanik, Anil K. Saksena, Yan-Hui Liu, Pradip R. Das, Olga Sarre, Ashit K. Ganguly

Journal:

Journal of the American Society for Mass Spectrometry

Year:

1997

Language:

english

File:

PDF, 595 KB

english, 1997

40

Effect of segmental diffusion on irreversible, step growth polymerizations of ARB monomers

Anil Kumar, Kamal Saksena, John P. Foryt, Santosh K. Gupta

Journal:

Polymer Engineering & Science

Year:

1987

Language:

english

File:

PDF, 697 KB

english, 1987

41

Structure revision for the product derived from the base-promoted rearrangement of exo-2,3-epoxynorbornane-endo-5,6-carbonate

Anil K. Saksena, Pietro Mangiaracina, Raymond Brambilla, Andrew T. McPhail, Kay D. Onan

Journal:

Tetrahedron Letters

Year:

1978

Language:

english

File:

PDF, 282 KB

english, 1978

42

Depeptidization efforts on α-ketoamide inhibitors of HCV NS3-4A serine protease: Effect on HCV replicon activity

Stéphane L. Bogen, Sumei Ruan, Rong Liu, Sony Agrawal, John Pichardo, Andrew Prongay, Bahige Baroudy, Anil K. Saksena, Viyyoor Girijavallabhan, F. George Njoroge

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

2006

Language:

english

File:

PDF, 312 KB

english, 2006

43

A highly stereoselective approach to novel 2,2,4-trisubstituted pyrrolidines by halocylization: key intermediates towards syntheses of nitrogen analogs of Noxafil®

Jinping L McCormick, Rebecca Osterman, Tze-Ming Chan, Pradip R Das, Birendra N Pramanik, Ashit K Ganguly, Viyyoor M Girijavallabhan, Andrew T McPhail, Anil K Saksena

Journal:

Tetrahedron Letters

Year:

2003

Language:

english

File:

PDF, 122 KB

english, 2003

44

Recent studies on veratrum alkaloids: a new reaction of sodium triacetoxyborohydride [NaBH(OAc)3]

Anil K. Saksena, Pietro Mangiaracina

Journal:

Tetrahedron Letters

Year:

1983

Language:

english

File:

PDF, 226 KB

english, 1983

45

Structure elucidation of Sch 49088, a novel everninomicin antibiotic containing an unusual hydroxylamino-ether sugar, everhydroxylaminose

Anil K. Saksena, Edwin Jao, Bruce Murphy, Doris Schumacher, Tze-Ming Chan, Mohindar S. Puar, John K. Jenkins, Donal Maloney, Mayra Cordero, Birendra N. Pramanik, Peter Bartner, Pradip R. Das, Andrew T

Journal:

Tetrahedron Letters

Year:

1998

Language:

english

File:

PDF, 319 KB

english, 1998

46

The synthesis of 2,2,24- trisubstituted oxetanes as new azole antifungal agents

Dinanath F. Rane, Viyyoor M. Girijavallabhan, Mohindar S. Puar, Anil K. Saksena, David Loebenberg, Raolo M. Parmegiani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 433 KB

english, 1994

47

Enantioselective synthesis of the optical isomers of broad-spectrum orally active antifungal azoles, Sch 42538 and Sch 45012

Anil K. Saksena, Viyyoor M. Girijavallabhan, Raymond G. Lovey, Russell E. Pike, Jagdish A. Desai, Ashit K. Ganguly, Roberta S. Hare, David Loebenberg, Anthony Cacciapuoti, Raulo M. Parmegiani

Journal:

Bioorganic & Medicinal Chemistry Letters

Year:

1994

Language:

english

File:

PDF, 488 KB

english, 1994

48

Enantioselective syntheses of carbocyclic ribavirin and its analogs: linear versus convergent approaches

Rongze Kuang*, Ashit K Ganguly*, Tze-Ming Chan, Birendra N Pramanik, David J Blythin, Andrew T McPhail, Anil.K Saksena

Journal:

Tetrahedron Letters

Year:

2000

Language:

english

File:

PDF, 86 KB

english, 2000

49

Characterization of resistance mutations against HCV ketoamide protease inhibitors

Xiao Tong, Stephane Bogen, Robert Chase, V. Girijavallabhan, Zhuyan Guo, F. George Njoroge, Andrew Prongay, Anil Saksena, Angela Skelton, Ellen Xia, Robert Ralston

Journal:

Antiviral Research

Year:

2008

Language:

english

File:

PDF, 612 KB

english, 2008

50

Clinical and Socioeconomic Profile of Patients With Malignant Ventricular Arrhythmias in 1993 to 1995

Michael J Domanski, MD, Sanjeev Saksena, MD, George Wyse, MD, Al Hallstrom, PhD, Eleanor B Schron, MS, Anil Nanda, BS, Anita Nanda, BS, Steven Kutalek, MD

Journal:

The American Journal of Cardiology

Year:

1997

Language:

english

File:

PDF, 129 KB

english, 1997